Force sharing and force generation by two teams of elastically coupled molecular motors.

ABSTRACT: Many active cellular processes such as long-distance cargo transport, spindle organization, as well as flagellar and ciliary beating are driven by molecular motors. These motor proteins act collectively and typically work in small teams. One particularly interesting example is two teams of antagonistic motors that pull a common cargo into opposite directions, thereby generating mutual interaction forces. Important issues regarding such multiple motor systems are whether or not motors from the same team share their load equally, and how the collectively generated forces depend on the single motor properties. Here we address these questions by introducing a stochastic model for cargo transport by an arbitrary number of elastically coupled molecular motors. We determine the state space of thi

SUBMITTER: Ucar MC 

PROVIDER: S-EPMC6345805 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature