Working memory performance in the elderly relates to theta-alpha oscillations and is predicted by parahippocampal and striatal integrity.

ABSTRACT: The ability to maintain information for a short period of time (i.e. working memory, WM) tends to decrease across the life span with large inter-individual variability; the underlying neuronal bases, however, remain unclear. To address this issue, we used a multimodal imaging approach (voxel-based morphometry, diffusion-tensor imaging, electroencephalography) to test the contribution of brain structures and neural oscillations in an elderly population. Thirty-one healthy elderly participants performed a change-detection task with different load conditions. As expected, accuracy decreased with increasing WM load, reflected by power modulations in the theta-alpha band (5-12 Hz). Importantly, these power changes were directly related to the tract strength between parahippocampus and parietal

SUBMITTER: Steiger TK 

PROVIDER: S-EPMC6345832 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature