Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC6345925 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Park Jieun J Cho Yong-Hee YH Shin Wook-Jin WJ Lee Sang-Kyu SK Lee JaeHeon J Kim Taehyung T Cha Pu-Hyeon PH Yang Jee Sun JS Cho Jaebeom J Min Do Sik DS Han Gyoonhee G Lee Ho-Young HY Choi Kang-Yell KY
Scientific reports 20190124 1
The epidermal growth factor receptor (EGFR) inhibitors such as erlotinib and gefitinib are widely used for treatment of non-small cell lung cancer (NSCLC), but they have shown limited efficacy in an unselected population of patients. The KRAS mutations, which are identified in approximately 20% of NSCLC patients, have shown to be associated with the resistance to the EGFR tyrosine kinase inhibitors (TKIs). Currently, there is no clinically available targeted therapy which can effectively inhibit ...[more]