Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of drug trials and clinical care. In this study we explored stratification through a crowdsourcing approach, the DREAM Prize4Life ALS Stratification Challenge. Using data from >10,000 patients from ALS clinical trials and 1479 patients from community-based patient registers, more than 30 teams developed new approaches for machine learning and clustering, outperforming the best current predictions of disease outcome. We propose a new method to integrate and analyze patient clusters across methods, showing a clear pattern of consistent and clinically relevant sub-groups of patients that also

SUBMITTER: Kueffner R 

PROVIDER: S-EPMC6345935 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature