Sonic hedgehog signaling is negatively regulated in reactive astrocytes after forebrain stab injury.

ABSTRACT: Following injury to the central nervous system, astrocytes perform critical and complex functions that both promote and antagonize neural repair. Understanding the molecular signaling pathways that coordinate their diverse functional properties is key to developing effective therapeutic strategies. In the healthy, adult CNS, Sonic hedgehog (Shh) signaling is active in mature, differentiated astrocytes. Shh has been shown to undergo injury-induced upregulation and promote neural repair. Here, we investigated whether Shh signaling mediates astrocyte response to injury. Surprisingly, we found that following an acute, focal injury, reactive astrocytes exhibit a pronounced reduction in Shh activity in a spatiotemporally-defined manner. Shh signaling is lost in reactive astrocytes at the lesion

SUBMITTER: Allahyari RV 

PROVIDER: S-EPMC6345977 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature