Cysteine residues in mitochondrial intermembrane space proteins: more than just import.

ABSTRACT: The intermembrane space (IMS) is a very small mitochondrial sub-compartment with critical relevance for many cellular processes. IMS proteins fulfil important functions in transport of proteins, lipids, metabolites and metal ions, in signalling, in metabolism and in defining the mitochondrial ultrastructure. Our understanding of the IMS proteome has become increasingly refined although we still lack information on the identity and function of many of its proteins. One characteristic of many IMS proteins are conserved cysteines. Different post-translational modifications of these cysteine residues can have critical roles in protein function, localization and/or stability. The close localization to different ROS-producing enzyme systems, a dedicated machinery for oxidative protein folding, a

SUBMITTER: Habich M 

PROVIDER: S-EPMC6346212 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature