Second primary cancer after female breast cancer: Familial risks and cause of death.

ABSTRACT:

Background

With continuous increases in survival rates following breast cancer (BC) diagnosis, the challenge of multiple primary cancers has become an issue. The data on familial risk of SPCs after BC diagnosis and the related mortality in BC patients are scarce.

Methods

A total of 87 752 female BC patients were followed for SPC diagnoses and records of death. Relative risks (RRs) of SPC in BC patients who had first-degree relatives (parents or siblings) affected by the same cancer were compared to the patients without family history. Causes of death were compared between patients with and without SPC.

Results

After a median follow-up of 5 years, 14 952 BC patients developed SPCs, among which 10 280 (68.8%) had first-degree relatives diagnosed with cancer. Familial ri

SUBMITTER: Zheng G 

PROVIDER: S-EPMC6346247 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature