The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury.

ABSTRACT:

Background

Pediatric traumatic brain injury (TBI) is a leading cause of death and disability. Polymorphisms in the apolipoprotein E ( APOE) gene have been linked to cerebral vasospasm (CV) and poor outcomes in adults with TBI, yet these associations remain poorly defined in children.

Objective

We examined the effect of the relationship between APOE polymorphisms and CV on functional outcomes in children with a TBI.

Method

This prospective, descriptive study examined 60 children (aged 10 days to 15 years) with a TBI. Data included demographic information, genetic sampling for the APOE gene and single-nucleotide polymorphisms (SNPs; rs405509, rs429358, rs7412), and daily transcranial Doppler ultrasounds to evaluate for CV. We examined Glasgow Outcome Scale-Extended Pedi

SUBMITTER: Reuter-Rice K 

PROVIDER: S-EPMC6346318 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature