Synthesis of amorpha-4,11-diene from dihydroartemisinic acid.

ABSTRACT: Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography.

SUBMITTER: Schwertz G 

PROVIDER: S-EPMC6346372 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature