Mild complexation protocol for chiral Cp^xRh and Ir complexes suitable for in situ catalysis.

ABSTRACT: A practical complexation method for chiral cyclopentadienyl (Cp^x) iridium and rhodium complexes is described. The procedure uses the free Cp^xH with stable and commercially available rhodium(i) and iridium(i) salts without base or additive. The conditions are mild and do not require the exclusion of air and moisture. A salient feature is the suitability for in situ complexations enhancing the user-friendliness of Cp^x ligands in asymmetric catalysis. DFT-calculations confirm an intramolecular proton abstraction pathway by either the bound acetate or methoxide. Furthermore, the superior facial selectivity of the proton abstraction step enabled the development of TMS-containing trisubstituted Cp^x ligands which display improved enantioselectivi

SUBMITTER: Audic B 

PROVIDER: S-EPMC6346397 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature