Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection.

ABSTRACT:

Background

Infectious diseases are still a leading cause of death and, with the emergence of drug resistance, pose a great threat to human health. New drugs and strategies are thus urgently needed to improve treatment efficacy and limit drug-associated side effects. Nanotechnology-based drug delivery systems are promising approaches, offering hope in the fight against drug resistant bacteria. However, how nanocarriers influence the response of innate immune cells to bacterial infection is mostly unknown.

Results

Here, we used Mycobacterium tuberculosis as a model of bacterial infection to examine the impact of mannose functionalization of chitosan nanocarriers (CS-NCs) on the human macrophage response. Both ungrafted and grafted CS-NCs were similarly internalized by macropha

SUBMITTER: Coya JM 

PROVIDER: S-EPMC6346558 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature