Leptin-deficient mice have altered three-dimensional growth plate histomorphometry.

ABSTRACT:

Background

Leptin is an adipokine that regulates energy homeostasis and is also needed for normal bone growth and maintenance. Mutation in the lep gene, which characterizes the ob/ob mouse model, results in the development of obesity and type 2 diabetes mellitus, as well as reduced limb bone length and increased fracture risk. However, the relationship between limb bone length and growth plate cartilage structure in obese diabetic adolescents is incompletely understood. Here, we tested the hypothesis that leptin deficiency affects the microstructure of growth plate cartilage in juvenile ob/ob mice.

Methods

Tibial growth plate cartilage structure was compared between lean and obese, leptin-deficient (ob/ob) female mice aged 10 weeks. We used confocal laser scanning mic

SUBMITTER: Hung J 

PROVIDER: S-EPMC6346570 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature