A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection.

ABSTRACT: Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically distinct chimpanzee adenovirus (ChAd3, ChAd63) vector priming followed by modified vaccinia Ankara (MVA) boosts, for simultaneous delivery of HCV non-structural (NSmut) and HIV-1 conserved (HIVconsv) region immunogens. Methods: We conducted a phase I trial in which 33 healthy volunteers were sequentially enrolled and vaccinated via the intramuscular route as follows: 9 received ChAd3-NSmut [2.5 × 10¹⁰ vp] and MVA-NSmut [2 × 10⁸ pfu] at weeks 0 and 8, respectively; 8 received ChAdV63.HIVconsv [5 × 10¹⁰ vp] and MVA.HIVconsv [2 × 1

SUBMITTER: Hartnell F 

PROVIDER: S-EPMC6346592 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature