Nonequivalent lethal equivalents: Models and inbreeding metrics for unbiased estimation of inbreeding load.

ABSTRACT: Inbreeding depression, the deterioration in mean trait value in progeny of related parents, is a fundamental quantity in genetics, evolutionary biology, animal and plant breeding, and conservation biology. The magnitude of inbreeding depression can be quantified by the inbreeding load, typically measured in numbers of lethal equivalents, a population genetic quantity that allows for comparisons between environments, populations or species. However, there is as yet no quantitative assessment of which combinations of statistical models and metrics of inbreeding can yield such estimates. Here, we review statistical models that have been used to estimate inbreeding load and use population genetic simulations to investigate how unbiased estimates can be obtained using genomic and pedigree-based

SUBMITTER: Nietlisbach P 

PROVIDER: S-EPMC6346663 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature