Early <i>Plasmodium</i>-induced inflammation does not accelerate aging in mice.

ABSTRACT: Aging is associated with a decline of performance leading to reduced reproductive output and survival. While the antagonistic pleiotropy theory of aging has attracted considerable attention, the molecular/physiological functions underlying the early-life benefits/late-life costs paradigm remain elusive. We tested the hypothesis that while early activation of the inflammatory response confers benefits in terms of protection against infection, it also incurs costs in terms of reduced reproductive output at old age and shortened longevity. We infected mice with the malaria parasite Plasmodium yoelii and increased the inflammatory response using an anti-IL-10 receptor antibody treatment. We quantified the benefits and costs of the inflammatory response during the acute phase of the infe

SUBMITTER: Lippens C 

PROVIDER: S-EPMC6346666 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature