Age at menarche and osteoporosis: A Mendelian randomization study.

ABSTRACT:

Purpose

Traditional epidemiological studies suggest that there is an association between age at menarche (years) (AAM) and bone mineral density (BMD) at the sites of the femoral neck and lumbar spine (FNK and LS BMD), indicating a potentially important relationship between AAM and the development of osteoporosis (OP). However, these findings may be influenced by unmeasured confounding factors that can obscure the true relationship between the phenotypic traits. Therefore, we performed Mendelian randomization (MR) analyses to determine whether there is a causal relationship between AAM and BMD (FNK and LS BMD), where late AAM may increase the risk of developing OP.

Methods

Adopting a two-sample MR approach we incorporated genome-wide association (GWAS) summary statistics from

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6346741 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature