Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis.

ABSTRACT:

Background

Frequent whole blood donations increase the prevalence of iron depletion in blood donors, which may subsequently interfere with normal erythropoiesis. The purpose of this study was to evaluate the associations between donation frequency and red blood cell (RBC) storage stability in a racially/ethnically diverse population of blood donors.

Study design

Leukoreduced RBC concentrate-derived samples from 13,403 donors were stored for 39 to 42 days (1-6°C) and then evaluated for storage, osmotic, and oxidative hemolysis. Iron status was evaluated by plasma ferritin measurement and self-reported intake of iron supplements. Donation history in the prior 2 years was obtained for each subject.

Results

Frequent blood donors enrolled in this study were likely to be wh

SUBMITTER: Kanias T 

PROVIDER: S-EPMC6347021 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature