Catalase-dependent H2O2 consumption by cardiac mitochondria and redox-mediated loss in insulin signaling.

ABSTRACT: We have recently demonstrated that catalase content in mouse cardiac mitochondria is selectively elevated in response to high dietary fat, a nutritional state associated with oxidative stress and loss in insulin signaling. Catalase and various isoforms of glutathione peroxidase and peroxiredoxin each catalyze the consumption of H₂O₂ Catalase, located primarily within peroxisomes and to a lesser extent mitochondria, has a low binding affinity for H₂O₂ relative to glutathione peroxidase and peroxiredoxin. As such, the contribution of catalase to mitochondrial H₂O₂ consumption is not well understood. In the current study, using highly purified cardiac mitochondria challenged with micromolar concentrations of H₂O

SUBMITTER: Rindler PM 

PROVIDER: S-EPMC6347072 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature