Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease.

ABSTRACT: There is an ever-increasing recognition that bile acids are not purely simple surfactant molecules that aid in lipid digestion, but are a family of molecules contributing to a diverse range of key systemic functions in the host. It is now also understood that the specific composition of the bile acid milieu within the host is related to the expression and activity of bacterially-derived enzymes within the gastrointestinal tract, as such creating a direct link between the physiology of the host and the gut microbiota. Coupled to the knowledge that perturbation of the structure and/or function of the gut microbiota may contribute to the pathogenesis of a range of diseases, there is a high level of interest in the potential for manipulation of the gut microbiota-host bile acid axis as a novel

SUBMITTER: Mullish BH 

PROVIDER: S-EPMC6347095 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature