Association of clinical outcomes in metastatic breast cancer patients with circulating tumour cell and circulating cell-free DNA.

ABSTRACT:

Background

Both circulating tumour cell (CTC) and total circulating cell-free DNA (ccfDNA) predict cancer patient prognosis. However, no study has explored the prognostic value of the combined use of CTC and ccfDNA. We aimed to investigate individual and joint effects of CTC and ccfDNA on clinical outcomes of metastatic breast cancer (MBC) patients.

Methods

We collected 227 blood samples from 117 MBC patients. CTCs were enumerated using the CellSearch System. ccfDNAs were quantified by quantitative real-time polymerase chain reaction and Qubit fluorometer. The individual and joint effects of CTC and ccfDNA levels on patient progression-free survival (PFS) and overall survival (OS) were analysed using Cox proportional hazards models.

Results

Compared to patients with <

SUBMITTER: Ye Z 

PROVIDER: S-EPMC6347110 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature