Synthetic lethality guiding selection of drug combinations in ovarian cancer.

ABSTRACT:

Background

Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but simultaneous loss of both gene functions results in lethality. Targeting synthetic lethal interactions with drug combinations promises increased efficacy in tumor therapy.

Materials and methods

We established a set of synthetic lethal interactions using publicly available data from yeast screens which were mapped to their respective human orthologs using information from orthology databases. This set of experimental synthetic lethal interactions was complemented by a set of predicted synthetic lethal interactions based on a set of protein meta-data like e.g. molecular pathway assignment. Based on the combined se

SUBMITTER: Heinzel A 

PROVIDER: S-EPMC6347359 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature