Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.

ABSTRACT: BACKGROUND:Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TRE exhibits an extraordinary ability to protect cells against different kinds of stresses through activation of autophagy. However, the effect of TRE on the heart during stress has never been tested. OBJECTIVES:This study evaluated the effects of TRE administration in a mouse model of chronic ischemic remodeling. METHODS:Wild-type (WT) or beclin1+/- mice were subjected to permanent ligation of the left anterior descending artery (LAD) and then treated with either placebo or trehalose (1 mg/g/day intraperitoneally for 48 h, then 2% in the drinking water). After 4 weeks, echocardiographic, hemodynamic, gravimetric, histological, and biochemical analyses were conducted. RESULTS:TRE reduced left

SUBMITTER: Sciarretta S 

PROVIDER: S-EPMC6347412 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature