Challenges in Predicting Recurrence After Resection of Node-Negative Non-Small Cell Lung Cancer.

ABSTRACT:

Background

One in 5 patients with completely resected early-stage non-small cell lung cancer will recur within 2 years. Risk stratification may facilitate a personalized approach to the use of adjuvant therapy and surveillance imaging. We developed a prediction model for recurrence based on five clinical variables (tumor size and grade, visceral pleural and lymphovascular invasion, and sublobar resection), and tested the hypothesis that the addition of several new molecular markers of poor long-term outcome (vascular endothelial growth factor C; microRNA precursors 486 and 30d) would enhance prediction.

Methods

We performed a retrospective cohort study of patients with completely resected, node-negative non-small cell lung cancer from 2011 to 2014 (follow-up through 2016) us

SUBMITTER: Thornblade LW 

PROVIDER: S-EPMC6347463 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature