Dopamine Release in Antidepressant-Naive Major Depressive Disorder: A Multimodal [¹¹C]-(+)-PHNO Positron Emission Tomography and Functional Magnetic Resonance Imaging Study.

ABSTRACT:

Background

Mesolimbic dopamine system dysfunction is believed to contribute to major depressive disorder (MDD), but molecular neuroimaging of striatal dopamine neurotransmission has yielded mixed results, possibly owing to limited sensitivity of antagonist radioligands used with positron emission tomography to assess dopamine release capacity. This study used an agonist radioligand with agonist challenge to assess dopamine release capacity and D₂/D₃ receptor availability in MDD.

Methods

Twenty-six treatment-naive adults with MDD and 26 healthy comparison participants underwent functional magnetic resonance imaging during a probabilistic reinforcement task, and positron emission tomography with the D₃-preferring ligand [¹¹C]-(+)-PHN

SUBMITTER: Schneier FR 

PROVIDER: S-EPMC6347467 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature