Urinary tungsten and incident cardiovascular disease in the Strong Heart Study: An interaction with urinary molybdenum.

ABSTRACT:

Background

Tungsten (W) interferes with molybdenum (Mo) binding sites and has been associated with prevalent cardiovascular disease (CVD). We evaluated if (1) W exposure is prospectively associated with incident CVD and (2) the association between urinary W levels and incident CVD is modified by urinary Mo levels.

Methods

We estimated multi-adjusted hazard ratios (HRs) for incident CVD outcomes by increasing W levels for 2726 American Indian participants in the Strong Heart Study with urinary metal levels measured at baseline (1989-1991) and CVD events ascertained through 2008.

Results

Increasing levels of baseline urinary W were not associated with incident CVD. Fully-adjusted HRs (95% CIs) of incident CVD comparing a change in the IQR of W levels for those in the lo

SUBMITTER: Nigra AE 

PROVIDER: S-EPMC6347476 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature