Lesion segmentation for MR spectroscopic imaging using the convolution difference method.

ABSTRACT:

Purpose

Delineation of lesion boundaries from volumetric MRSI metabolite ratio maps using a method that accounts for the spatial response function of the acquisition and variable spectral quality and is robust to signal heterogeneity within the lesion.

Methods

A novel method for lesion segmentation, termed convolution difference, has been developed that is robust to signal heterogeneity within the lesion and to differences in the spatial response function. Procedures are described for processing metabolite ratio maps and to exclude regions of inadequate spectral quality. This method was evaluated using computer simulations, and the results were compared with an iterative thresholding technique that determines an optimal amplitude threshold, and with the use of a fixed amplit

SUBMITTER: Maudsley AA 

PROVIDER: S-EPMC6347534 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature