Dynamic diffusion-weighted hyperpolarized ¹³ C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport.

ABSTRACT:

Purpose

To develop a pulse sequence to dynamically measure the ADC of hyperpolarized substrates during their perfusion, metabolic conversion, and transport.

Methods

We proposed a slice-selective double spin echo sequence for dynamic hyperpolarized ¹³ C diffusion-weighted imaging. The proposed pulse sequence was optimized for a high field preclinical scanner through theoretical analysis and simulation. The performance of the method was compared to non-slice-selective double spin echo via in vivo studies. We also validated the sequence for dynamic ADC measurement in both phantom studies and transgenic mouse model of prostate cancer studies.

Results

The optimized pulse sequence outperforms the traditional sequence with smaller saturation effects on the magneti

SUBMITTER: Zhu X 

PROVIDER: S-EPMC6347546 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature