Psychosocial Correlates of Monocyte Activation and HIV Persistence in Methamphetamine Users.

ABSTRACT: This cross-sectional study investigated the associations of psychosocial factors relevant to recovery from substance use disorders with monocyte activation and HIV persistence in a sample of 84 HIV-positive, methamphetamine-using sexual minority men with undetectable HIV viral load (<40 copies/mL). We examined if psychosocial factors were associated with decreased soluble CD14 (sCD14) and lower proviral HIV DNA. Multiple linear regression models adjusted for age, anti-retroviral therapy regimen, and CD4+ T-cell count. Time on ART was also included in models examining proviral HIV DNA. Greater self-efficacy for managing methamphetamine triggers and higher social support for abstinence were independently associated with lower sCD14. Greater social support for abstinence was also independentl

SUBMITTER: Grosgebauer K 

PROVIDER: S-EPMC6347547 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature