Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction.

ABSTRACT:

Background

Hypertension-induced microvascular brain injury is a major vascular contributor to cognitive impairment and dementia. We hypothesized that chronic hypoxia promotes the hyperphosphorylation of tau and cell death in an accelerated spontaneously hypertensive stroke prone rat model of vascular cognitive impairment.

Methods

Hypertensive male rats (n = 13) were fed a high salt, low protein Japanese permissive diet and were compared to Wistar Kyoto control rats (n = 5).

Results

Using electron paramagnetic resonance oximetry to measure in vivo tissue oxygen levels and magnetic resonance imaging to assess structural brain damage, we found compromised gray (dorsolateral cortex: p = .018) and white matter (corpus callosum: p = .016; external capsule: p = .049) structu

SUBMITTER: Raz L 

PROVIDER: S-EPMC6347559 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature