Shared heritability and functional enrichment across six solid cancers.

ABSTRACT: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r_g = 0.57, p = 4.6 × 10^-8), breast and ovarian cancer (r_g = 0.24, p = 7 × 10^-5), breast and lung cancer (r_g = 0.18, p =1.5 × 10^-6) and breast and colorectal cancer (r_g = 0.15, p 

SUBMITTER: Jiang X 

PROVIDER: S-EPMC6347624 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature