Host genetic variants in sepsis risk: a field synopsis and meta-analysis.

ABSTRACT:

Background

Published data revealed that host genetic variants have a substantial influence on sepsis susceptibility. However, the results have been inconsistent. We aimed to systematically review the published studies and quantitatively evaluate the effects of these variants on the risk of sepsis.

Methods

We searched the PubMed, EMBASE, Medline, Web of Knowledge, and HuGE databases to identify studies that investigated the associations between genetic variants and sepsis risk. Then, we conducted meta-analyses of the associations for genetic variants with at least three study populations and applied the Venice criteria to assess the association result credibility.

Results

A literature search identified 349 eligible articles that investigated 405 variants of 172 distinc

SUBMITTER: Lu H 

PROVIDER: S-EPMC6347778 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature