MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma.

ABSTRACT:

Background

Glioblastoma is a malignant brain tumor characterized by rapid growth, diffuse invasion and therapeutic resistance. We recently used microRNA expression profiles to subclassify glioblastoma into five genetically and clinically distinct subclasses, and showed that microRNAs both define and contribute to the phenotypes of these subclasses. Here we show that miR-29a activates a multi-faceted growth and invasion program that promotes glioblastoma aggressiveness.

Methods

microRNA expression profiles from 197 glioblastomas were analyzed to identify the candidate miRNAs that are correlated to glioblastoma aggressiveness. The candidate miRNA, miR-29a, was further studied in vitro and in vivo.

Results

Members of the miR-29 subfamily display increased expression in t

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6347789 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature