Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials.

ABSTRACT:

Objective

To assess the benefits and harms of pregabalin in the management of neuropathic pain.

Design

Rapid review and meta-analysis of phase III, randomised, placebo-controlled trials.

Participants

Adults aged 18 years and above with neuropathic pain defined according to the International Association for the Study of Pain criteria.

Interventions

Pregabalin or placebo.

Primary and secondary outcome measures

Our primary outcomes were pain (as measured using validated scales) and adverse events. Our secondary outcomes were sleep disturbance, quality of life, Patient Global Impression of Change, Clinician Global Impression scale, anxiety and depression scores, overall discontinuations and discontinuations because of adverse events.

Results

We includ

SUBMITTER: Onakpoya IJ 

PROVIDER: S-EPMC6347863 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature