Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study aimed to investigate the association between the use of isotretinoin and the risk of depression in patients with acne.

Design

This was a meta-analysis in which the standardised mean difference (SMD) and the relative risk (RR) were used for data synthesis employing the random-effects model.

Setting

Studies were identified via electronic searches of PubMed, Embase and the Cochrane Library from inception up to 28 December 2017.

Participants

Patients with acne.

Interventions

Studies comparing isotretinoin with other interventions in patients with acne were included.

Results

Twenty studies were selected. The analysis of 17 studies showed a significant association of the use of isotretinoin with improved symptoms compared with the b

SUBMITTER: Li C 

PROVIDER: S-EPMC6347928 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature