Insulin dysregulation plays a critical role in colon inflammation: a bioinformatics approach.

ABSTRACT:

Aim

Evaluating and screening of genes related to colorectal inflammation of mice for finding critical ones in this disease was the aim of this study.

Background

Many studies are shown direct relationship between inflammation and colorectal cancer onset and development. Several molecular aspects of inflammation are investigated to discover molecular mechanism of this disease.

Methods

Profiles of differentially expressed genes (DEGs) of mice inflamed colorectal tissue in comparison with normal samples are obtained from Gene Expression Omnibus (GEO) database. The significant and characterized DEGs were screened via protein-protein interaction (PPI) network. Hubs of the network were determined and backbone network was constructed. Moreover, action network for the critical

SUBMITTER: Naderi N 

PROVIDER: S-EPMC6347978 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature