Variants in two gene members of the TNF ligand superfamily and hepatitis C virus chronic disease.

ABSTRACT:

Aim

To assess the possible correlation between single nucleotide polymorphisms (SNPs) of two members of TNF ligand superfamily genes, tumor necrosis factor-α (TNF-α) and lymphotoxin-α (LTA), and HCV chronic disease.

Background

The causes of disease progression from hepatitis C virus (HCV) infection to chronic liver disease still remains unclear. Abnormal production of the cytokines alleged to be contributed to progression of the disease or viral persistence. Regulatory mechanisms that control the production of cytokines including genetic polymorphisms, especially at coding/regulatory regions of genes, may affect expression and secretion of the cytokines.

Methods

In this case-control investigation, 258 individuals with serologically proven chronic HCV infection and 277

SUBMITTER: Baradaran Ghavami S 

PROVIDER: S-EPMC6347984 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature