¹³C-lutein is differentially distributed in tissues of an adult female rhesus macaque following a single oral administration: a pilot study.

ABSTRACT: Despite the growing awareness regarding lutein's putative roles in eyes and brain, its pharmacokinetics and tissue distribution in primates have been poorly understood. We hypothesized that ¹³C-lutein will be differentially distributed into tissues of an adult rhesus macaque (Macaca mulatta) 3 days following a single oral dose. After a year of prefeeding a diet supplemented with unlabeled lutein (1 μmol/kg/d), a 19-year-old female was dosed with 1.92 mg of highly enriched ¹³C-lutein. Tissues of a nondosed, lutein-fed monkey were used as a reference for natural abundance of ¹³C-lutein. On the third day postdose, plasma and multiple tissues were collected. Lutein was quantified by high-performance liquid chromatography-photodiode array detector, and ^13</

SUBMITTER: Jeon S 

PROVIDER: S-EPMC6348040 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature