Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.

ABSTRACT:

Rationale & objective

Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.

Study design

Cross-sectional individual participant-level analyses in a global consortium.

Setting & study populations

17 CKD and 38 general population and high-risk cohorts.

Selection criteria for studies

Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension.<

SUBMITTER: Inker LA 

PROVIDER: S-EPMC6348050 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature