Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men.

ABSTRACT:

Background/objectives

Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA, and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan.

Subjects/methods

The Shiga Epidemiological Study of Subclinical Atherosclerosis examined a population-based sample of 1074 men aged 40-79 in 2006-08 for computed tomography-measured CAC score (CCS), a well-established biomarker of coronary atherosclerosis, CAC density score (CDS), a potential marker of plaque stabiliza

SUBMITTER: Sekikawa A 

PROVIDER: S-EPMC6348058 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature