Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway.

ABSTRACT: In the tumor microenvironment, inflammatory cells and molecules influence almost every process; among them, interleukin-23 (IL-23) is a pro-inflammatory molecule that exhibits pro- or anti-tumor properties, but both activities remain poorly understood. In this study, we investigated the effect of extracellular IL-23 in IL-23 receptor-positive (IL-23R⁺) esophageal squamous cell carcinoma (ESCC) and explored the mechanisms underlying this effect. We analyzed ESCC tumor tissues by immunohistochemical and immunofluorescence staining and found that IL-23, which was highly expressed, co-localized with Oct-4A in IL-23R⁺ ESCC cells. In addition, IL-23 treatment significantly increased the accumulation of CD133⁺ cells and activated the Wnt and Notch signaling pathwa

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6348073 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature