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A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level.


ABSTRACT:

Background

To determine if the rs7079 polymorphism located in the 3' UTR of the angiotensinogen gene (AGT) altered AGT gene expression and the risk of lead poisoning. A case-control study and luciferase reporter gene assay identified a significant association between rs7079 variants and the risk of lead poisoning.

Results

Serum AGT levels were significantly higher in individuals carrying the rs7079 CA genotype, as compared to those carrying the rs7079 CC genotype. The binding of the miRNA mimics miR-31-5p and miR-584-5p to the 3' UTR of AGT differed based on which rs7079 variant was present, implying that AGT gene expression depends on the rs7079 variant carried.

Conclusions

The rs7079 C to A substitution reduced the binding of miR-31-5p/miR-584-5p to the 3' UTR of AGT, possibly altering the risk of lead poisoning.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6348078 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level.

Wu Yu Y   Wang Miaomiao M   Zhang Jinlong J   Sun Na N   Li Chunping C  

Hereditas 20190126


<h4>Background</h4>To determine if the rs7079 polymorphism located in the 3' UTR of the angiotensinogen gene (<i>AGT</i>) altered <i>AGT</i> gene expression and the risk of lead poisoning. A case-control study and luciferase reporter gene assay identified a significant association between rs7079 variants and the risk of lead poisoning.<h4>Results</h4>Serum AGT levels were significantly higher in individuals carrying the rs7079 CA genotype, as compared to those carrying the rs7079 CC genotype. Th  ...[more]

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