TREC and KREC Levels as a Predictors of Lymphocyte Subpopulations Measured by Flow Cytometry.

ABSTRACT: Primary immunodeficiency diseases (PID) is a heterogeneous group of disorders caused by genetic defects of the immune system, which manifests clinically as recurrent infections, autoimmune diseases, or malignancies. Early detection of other PID remains a challenge, particularly in older children due to milder and less specific symptoms, a low level of clinician PID awareness and poor provision of hospital laboratories with appropriate devices. T-cell recombination excision circles (TREC) and kappa-deleting element recombination circle (KREC) in a dried blood spot and in peripheral blood using real-time polymerase chain reaction (PCR) are used as a tool for severe combined immune deficiency but not in PID. They represent an attractive and cheap target for a more extensive use in clinical pr

SUBMITTER: Korsunskiy I 

PROVIDER: S-EPMC6348265 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature