Altered glial glutamate transporter expression in descending circuitry and the emergence of pain chronicity.

ABSTRACT:

Background

The glutamate type 1 transporter (GLT1) plays a major role in glutamate homeostasis in the brain. Although alterations of GLT1 activity have been linked to persistent pain, the significance of these changes is poorly understood. Focusing on the rostral ventromedial medulla, a key site in pain modulation, we examined the expression and function of GLT1 and related transcription factor kappa B-motif binding phosphoprotein (KBBP) in rats after adjuvant-induced hind paw inflammation.

Results

After inflammation, GLT1 and KBBP showed an early upregulation and gradual transition to downregulation that lasted throughout the eight-week observation period. Nitration of GLT1 was reduced at 30 min and increased at eight weeks after inflammation, suggesting an initial increase

SUBMITTER: Guo W 

PROVIDER: S-EPMC6348548 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature