Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma.

ABSTRACT:

Background

Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV₁. Provocation tests only use the large airways parameter FEV₁, although dyspnea is associated with both large- and small airways dysfunction. Aim of this study was to explore if adenosine 5'-monophosphate (AMP) and adenosine evoke an equal dyspnea sensation and if dyspnea associates better with large or small airways dysfunction.

Methods

We targeted large airways with AMP and small airways with dry powder adenosine in 59 asthmatic (ex)-smokers with ≥5 packyears, 14 ± 7 days apart. All subjects performed spirometry, impulse oscillometry (IOS), and Borg dyspnea score. In 36 subjects multiple breath nitrogen washout (M

SUBMITTER: Cox CA 

PROVIDER: S-EPMC6348600 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature