Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR.

ABSTRACT: Cadmium is a toxic pollutant that in recent decades has become more widespread in the environment due to anthropogenic activities, significantly increasing the risk of exposure. Concurrently, a continually growing body of research has begun to enumerate the harmful effects that this heavy metal has on human health. Consequently, additional research is required to better understand the mechanism and effects of cadmium at the molecular level. The main mechanism of cadmium toxicity is based on the indirect induction of severe oxidative stress, through several processes that unbalance the anti-oxidant cellular defence system, including the displacement of metals such as zinc from its native binding sites. Such mechanism was thought to alter the in vivo enzymatic activity of SOD1, one of the ma

SUBMITTER: Polykretis P 

PROVIDER: S-EPMC6348768 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature