Titanium Surface Properties Influence the Biological Activity and FasL Expression of Craniofacial Stromal Cells.

ABSTRACT: Mesenchymal stromal cells (MSCs) can be easily isolated form craniofacial bones during routine dentistry procedures. Due to their embryological origin from neural crest, they represent a suitable cell population to study cell-biomaterial interaction in the craniofacial field, including osteoinductive/osteointegrative processes. The biological and immunomodulatory properties of MSCs may be influenced by chemistry and topography of implant surfaces. We investigated if and how three different titanium surfaces, machined (MCH), sandblasted with resorbable blasting medium (RBM), and Ca⁺⁺-nanostructured (NCA), may affect biological activity, osseointegration, and immunomodulatory properties of craniofacial MSCs. Cell proliferation, morphology, osteogenic markers, and FasL were evaluat

SUBMITTER: Conserva E 

PROVIDER: S-EPMC6348805 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature