Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer.

ABSTRACT: TIGIT is an inhibitory immune checkpoint receptor and a putative target for novel immune therapies. Here, we analysed two different types of tissue microarrays of healthy lymphatic and various inflamed tissues, colorectal and lung cancers, as well as >1700 tumour samples from 86 different tumour entities for TIGIT and/or PD-1 by bright field and/or multiplex fluorescence immunohistochemistry. TIGIT was detected in CD8⁺ cytotoxic T cells, CD4⁺ T helper cells, FOXP3⁺ regulatory T cells, and NK cells, but not in CD11c⁺ dendritic cells, CD68⁺ macrophages, and CD20⁺ B lymphocytes. TIGIT expression paralleled that of PD-1. More than 70% of TIGIT⁺ cells were PD-1⁺, and more than 90% of the PD-1⁺ cel

SUBMITTER: Blessin NC 

PROVIDER: S-EPMC6348838 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature