Overlap of Characteristic Serological Antibodies in Rheumatoid Arthritis and Wheat-Related Disorders.

ABSTRACT:

Background and aims

Rheumatoid arthritis (RA) and celiac disease (CD) are members of the autoimmune disease family while they have been shown to share multiple aspects in epidemiology and clinical manifestations. The aim of this study was to assess the presence of wheat protein antibodies in RA seropositive subjects and the presence of RA diagnostic markers in subjects with seropositive wheat-related disorders including CD.

Methods

Serum samples were collected from 844 subjects with joint pain and/or gastrointestinal symptoms and tested by a CD panel (anti-tTG and anti-DGP), a Wheat Zoomer (WZ) antibody panel (IgG/IgA to 14 wheat proteins), and a RA panel (anti-CCP and anti-RF). Retrospective analysis was completed using de-identified clinical data and test results.

Resul

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6348907 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature