Association between lifetime risk of atrial fibrillation and mortality in the oldest old.

ABSTRACT:

Background

Age is the strongest predictor of atrial fibrillation (AF), yet little is known about AF incidence in the oldest old.

Hypothesis

AF incidence declines after age 90 years, and morbidity is compressed into a brief period at the end of life.

Methods

In this retrospective, longitudinal cohort study of patients (born 1905-1935), we examined cumulative lifetime incidence of AF and its impact on mortality. Data included records from 1 062 610 octogenarians, 317 161 nonagenarians, and 3572 centenarians. Kaplan-Meier curves were used to estimate cumulative incidence of AF by age group, incidence rates were compared using log-rank tests, and Cox proportional hazards model was used to estimate unadjusted hazard ratios. The primary outcome was AF incidence at age > 80 

SUBMITTER: Kheirbek RE 

PROVIDER: S-EPMC6349030 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature