Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy.

ABSTRACT:

Background

Adverse childhood experiences (ACEs), such as abuse or chronic stress, program an exaggerated adult inflammatory response to stress. Emerging rodent research suggests that the gut microbiome may be a key mediator in the association between early life stress and dysregulated glucocorticoid-immune response. However, ACE impact on inflammatory response to stress, or on the gut microbiome, have not been studied in human pregnancy, when inflammation increases risk of poor outcomes. The aim of this study was to assess the relationships among ACE, the gut microbiome, and cytokine response to stress in pregnant women.

Methods

Physically and psychiatrically healthy adult pregnant women completed the Adverse Childhood Experiences Questionnaire (ACE-Q) and gave a single stoo

SUBMITTER: Hantsoo L 

PROVIDER: S-EPMC6349044 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature